How Long After Taking Xanax Can You Take Hydroxyzine?

How Long After Taking Xanax Can You Take Hydroxyzine

When it comes to managing anxiety, it’s not uncommon for individuals to seek relief through prescription medications.

Two such medications, Xanax (alprazolam) and hydroxyzine, can be effective tools in the battle against anxiety.

But is it safe to use them together, and if so, what’s the best timing?

In this comprehensive guide, we’ll explore the interaction between these two drugs and answer the critical question – just how long after taking Xanax can you safely take hydroxyzine?

Can You Take Xanax and Hydroxyzine Together?

Can You Take Xanax and Hydroxyzine Together

The short answer is yes – you can take Xanax and hydroxyzine together.

Both medications have different mechanisms of action, which means they won’t interact or counteract each other.

However, it’s essential to note that both drugs are central nervous system (CNS) depressants, meaning they slow down brain activity and can cause drowsiness.

Therefore, taking them together can increase their sedative effects, making it crucial to take precautions when using both medications in conjunction.

It’s best to consult with your doctor or pharmacist before taking Xanax and hydroxyzine together, especially if you have any pre-existing health conditions or are taking other medications.

Reasons for Taking Xanax and Hydroxyzine Together

There are several reasons why a doctor may prescribe Xanax and hydroxyzine together.

  1. Treating Anxiety: Both drugs have been approved by the FDA for treating anxiety disorders, including generalized anxiety disorder (GAD) and panic disorder.
  2. Managing Insomnia: Xanax is sometimes prescribed off-label to help with insomnia, while hydroxyzine can also be used as a sleep aid due to its sedative effects.
  3. Potentiating the Effects of Xanax: Some individuals may require higher doses of Xanax for it to be effective. Taking hydroxyzine can potentiate its effects. This allows for lower dosages to achieve desired results.

Hydroxyzine for Xanax withdrawal

Another reason for taking hydroxyzine with Xanax is to manage withdrawal symptoms if someone is tapering off or quitting Xanax.

Withdrawal from benzodiazepines like Xanax can cause severe and uncomfortable symptoms, such as anxiety, insomnia, and seizures.

Hydroxyzine can help alleviate these symptoms by reducing the excitability of the brain and nervous system.

However, it’s essential to consult with a doctor before using hydroxyzine for Xanax withdrawal as it may not be suitable for everyone.

Also Read: Is it safe to combine Xanax and Losartan?

Interactions between Xanax and Hydroxyzine

While Xanax and hydroxyzine are generally safe to use together, there are still potential interactions to consider.

One of the main concerns is the increased risk of sedation and drowsiness when taking both medications simultaneously.

Other possible interactions include:

  • Respiratory Depression: Taking both drugs together can lead to respiratory depression, where breathing slows down and becomes shallow. This effect is more likely in individuals with pre-existing respiratory conditions.
  • Central Nervous System Depression: As mentioned earlier, both Xanax and hydroxyzine are CNS depressants. Taking them together can further suppress brain activity, leading to dizziness, confusion, and slowed reaction times.
  • Increased Side Effects: Combining Xanax and hydroxyzine can increase the likelihood of experiencing side effects such as blurred vision, dry mouth, and difficulty urinating.

How Long After Taking Xanax Can You Take Hydroxyzine?

How Long After Taking Xanax Can You Take Hydroxyzine

Generally, it’s recommended to wait at least 6-8 hours after taking Xanax before taking hydroxyzine.

This allows for the initial effects of Xanax to wear off and reduces the risk of interactions and side effects.

However, this timing may vary depending on factors such as individual sensitivity, dosage, and other medications being taken.

It’s crucial to follow your doctor’s instructions and consult with them if you have any concerns or questions.

Factors Affecting the Timing

  1. Dosage of Xanax: Higher doses of Xanax may take longer to wear off, so it’s essential to wait longer before taking hydroxyzine.
  2. Individual Sensitivity: Some individuals may be more sensitive to the sedative effects of these medications, and they may need to wait longer before taking hydroxyzine.
  3. Other Medications: If you’re taking other medications, especially those that also have sedative effects, it’s crucial to consult with your doctor before taking Xanax and hydroxyzine together. They may recommend a longer waiting period or adjust dosages accordingly.
  4. Pre-existing Health Conditions: Individuals with certain health conditions, such as liver or kidney disease, may need a longer waiting period between taking Xanax and hydroxyzine to avoid potential interactions.

Also Read: How soon can Xanax be taken after Omeprazole?

Risks and Considerations

While Xanax and hydroxyzine can be safely taken together, there are still some risks and considerations to keep in mind.

  1. Increased Sedation: As mentioned earlier, taking both medications can increase the sedative effects, leading to drowsiness and impairing cognitive function.
  2. Risk of Overdose: Combining Xanax and hydroxyzine can increase the risk of overdose, especially when taken in high doses or with other substances.
  3. Tolerance and Dependence: Both medications have a potential for tolerance and dependence, so it’s crucial to take them as prescribed and under medical supervision.
  4. Withdrawal Symptoms: Abruptly stopping medication can cause withdrawal symptoms. It’s crucial to follow your doctor’s instructions for tapering off or discontinuing use.

Description of Xanax (Alprazolam)

Xanax, also known by its generic name alprazolam, is a commonly prescribed medication for the treatment of anxiety disorders, panic attacks, and even depression.

It’s part of the benzodiazepine family and is known for its quick onset of action.

Mechanism of Action

Xanax functions by boosting the impact of a brain neurotransmitter known as gamma-aminobutyric acid (GABA).

GABA is responsible for reducing brain activity, making it an effective treatment for anxiety and panic disorders.

Side Effects

Common side effects of Xanax may include:

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Blurred vision
  • Difficulty concentrating.

Also Read: Does Xanax Assist in Alleviating Nerve Pain?

Description of Hydroxyzine

Hydroxyzine, also known by its brand name Vistaril, is a medication primarily used for the treatment of anxiety and itching.

It’s classified as an antihistamine and sedative.

Mechanism of Action

Hydroxyzine works by blocking the effects of histamine, a chemical produced in the body that causes allergic reactions and can also contribute to anxiety.

It also has sedative effects due to its ability to block certain brain receptors.

Side Effects

Common side effects of hydroxyzine may include:

  • Drowsiness
  • Dry mouth
  • Blurred vision
  • Constipation
  • Difficulty urinating.

Alternative Approaches to Anxiety and Insomnia

While Xanax and hydroxyzine can be effective in treating anxiety and insomnia, there are also alternative approaches that could be explored. These include:

  1. Cognitive Behavioral Therapy (CBT): CBT is a form of therapy that focuses on identifying and changing negative thought patterns and behaviors that contribute to anxiety. It has been shown to be an effective long-term treatment for anxiety disorders.
  2. Lifestyle Changes: Making changes to one’s lifestyle, such as incorporating regular exercise, practicing relaxation techniques, and maintaining a healthy diet, can also help reduce symptoms of anxiety and improve sleep.
  3. Natural Supplements: Certain natural supplements, such as melatonin, valerian root, and passionflower, have been shown to have calming effects and aid in promoting sleep. It’s essential to consult with a healthcare professional before taking any supplements, especially while on other medications.
  4. Mindfulness Practices: Mindfulness practices, such as meditation and yoga, can help alleviate symptoms of anxiety and promote better sleep by promoting relaxation and reducing stress.
  5. Prescription Alternatives: For those seeking alternatives to prescription medications, there are also non-benzodiazepine options such as buspirone and antidepressants that can be effective in treating anxiety and insomnia.


Xanax and hydroxyzine can be taken together, but it’s important to follow the recommended guidelines and consult with a healthcare professional if you have any concerns or questions.

Key Takeaways

  • Wait at least 6-8 hours after taking Xanax before taking hydroxyzine.
  • Factors such as dosage, individual sensitivity, other medications, and health conditions can affect the timing of when to take hydroxyzine after Xanax.
  • There are potential risks and considerations to keep in mind when combining Xanax and hydroxyzine.
  • Both medications have the potential for tolerance, dependence, and withdrawal symptoms.
  • Alternative approaches to anxiety and insomnia include cognitive behavioral therapy, lifestyle changes, natural supplements, mindfulness practices, and prescription alternatives.


Is it safe to combine Xanax and hydroxyzine?

It can be safe to combine Xanax with hydroxyzine, but the combination can lead to increased sedation and other side effects.

It’s essential to consult with a healthcare provider to determine if this combination is appropriate for you.

Can you develop a dependency on Xanax or hydroxyzine?

Yes, both Xanax and hydroxyzine can be habit-forming with long-term use.

It’s important to take them only as directed by a healthcare professional and to never stop taking them abruptly.

What are some signs that I might be experiencing an adverse reaction to Xanax or hydroxyzine?

Adverse reactions can vary depending on the individual, but some common signs include severe sedation, confusion, changes in mood, or difficulty breathing.

I missed a dose of Xanax. Can I take hydroxyzine as a substitute?

No, it’s not recommended to substitute one drug for another without consulting your doctor.

If you miss a dose of your prescribed medication, it’s best to follow your doctor’s instructions and not self-medicate with an alternative drug.

Are there any foods or drinks I should avoid while taking Xanax or hydroxyzine?

Alcohol should be avoided when taking Xanax or hydroxyzine, as it can increase the sedative effects of the drugs.

Also, grapefruit and grapefruit juice can interact with Xanax and should be used with caution.

Can you take Xanax and hydroxyzine on the same day?

As mentioned earlier, it is possible to take Xanax and hydroxyzine on the same day, but it’s important to wait at least 6-8 hours between doses.

It’s best to follow your doctor’s instructions and dosing schedule for each medication.

Useful Resources


The content of this article is provided for informational purposes only and should not be considered a replacement for professional medical advice, diagnosis, or treatment. It is important to seek professional medical advice and not disregard it or delay seeking it based on the information read here. While we strive to provide accurate and reliable information, we cannot guarantee its completeness, accuracy, reliability, suitability, or availability for any purpose. Using the information in this document is your responsibility and carries inherent risks. We are not liable for any losses or damages resulting from the use of our content.


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