Does Berberine Make Your Pee Yellow?

Does Berberine Make Your Pee Yellow


Berberine is a type of plant alkaloid that has been used in traditional Chinese medicine for centuries. It is commonly found in plants such as goldenseal, barberry, and Oregon grape root.

In recent years, berberine has become popular as a supplement because of its potential health benefits.

One common question that people have about berberine is whether or not it can make your pee yellow.

In this article, we will explore this question and provide some information about berberine.

Does Berberine Affect Urine Color?

The short answer to whether or not berberine can make your pee yellow is yes, it can. However, this change in urine color is completely harmless and temporary.

The Science Behind Yellow Urine

1. Berberine Metabolism: When you ingest berberine, your liver and intestines break it down into various metabolites. These metabolites can sometimes impart a yellow hue to your urine.

2. Pigmentation: The yellow coloration is due to the natural pigments in berberine, which, when metabolized, are excreted in the urine, giving it a distinctive yellow tint.

3. Urinary Concentration: Factors such as hydration levels can affect the concentration of these pigments in the urine. More concentrated urine is typically darker, so adequate hydration can influence the intensity of the yellow color.

4. Temporary Effect: The change in urine color is temporary and usually subsides once berberine is fully metabolized and excreted from the body. This usually takes a few hours to a couple of days, depending on individual metabolic rates.

Factors Influencing Urine Color

Several factors can influence the color of your urine besides the consumption of berberine:

1. Hydration Levels: Adequate hydration dilutes the pigments in the urine, making it lighter in color. Conversely, dehydration can make urine appear darker.

2. Diet: Foods rich in certain pigments, such as beets, carrots, and berries, can also alter the color of your urine.

3. Medications and Supplements: Some medications and dietary supplements, apart from berberine, can cause changes in urine color. For instance, vitamin B supplements can turn urine bright yellow.

4. Health Conditions: Certain health conditions, such as liver or kidney disease, can affect urine color. If you notice persistent changes in urine color that are not linked to diet or supplements, it is advisable to consult a healthcare provider.

5. Exercise: Intense physical activity can lead to dehydration, which may concentrate the pigments in your urine, making it darker.

Understanding these factors can help you better interpret changes in your urine color and identify whether they are related to berberine or other causes.

Other Side Effects of Berberine

Apart from temporarily affecting urine color, berberine may also cause other side effects in some individuals:

1. Digestive Issues: Some people may experience stomach upset, diarrhea, or constipation when taking berberine.

2. Low Blood Pressure: Berberine has been found to lower blood pressure in some studies. If you have low blood pressure or are taking medications for hypertension, it is essential to consult a healthcare provider before starting berberine supplementation.

3. Drug Interactions: Berberine may interact with certain medications like antibiotics and anticoagulants. It is advisable to seek medical advice before taking berberine if you are on any medication.

What to Do if You Notice Changes in Urine Color?

If you notice a change in the color of your urine while taking berberine, here’s what you can do:

Hydrate Well: Ensure you are drinking enough water throughout the day. Hydration can dilute the pigments and may help return your urine to its normal color.

Monitor Diet: Take note of any foods you’ve eaten that may also alter urine color, such as beets or carrots, and consider whether they could be the cause.

Review Medications and Supplements: Evaluate any other medications or supplements you are taking. Some, like vitamin B supplements, can cause similar changes.

Observe Duration: Temporary changes in urine color should resolve within a few hours to a couple of days. Keep track of how long the alteration persists.

Consult a Healthcare Provider: If the change in urine color is persistent and cannot be linked to diet, hydration, or supplements, it may be wise to seek medical advice to rule out underlying health conditions.

Also Read: Does Liquid IV Increase Urination?

Brief Overview of Berberine Benefits

Now that we’ve answered the question of whether or not berberine can make your pee yellow, let’s take a quick look at some potential health benefits of this supplement:

1. Blood Sugar Management: Berberine has been found to help lower blood sugar levels and improve insulin sensitivity in people with type 2 diabetes.

2. Cholesterol Regulation: Some studies suggest that berberine may aid in reducing LDL (bad) cholesterol and triglyceride levels while increasing HDL (good) cholesterol.

3. Weight Loss Support: Research has shown that berberine may assist in weight loss by decreasing appetite and promoting fat burning.

4. Anti-inflammatory Properties: Berberine exhibits anti-inflammatory properties, making it potentially beneficial for conditions such as arthritis and inflammatory bowel disease.

5. Antimicrobial Effects: Berberine has been shown to have antimicrobial effects, making it useful in combating various infections caused by bacteria, viruses, fungi, and parasites.


In conclusion, berberine can temporarily change the color of your urine to yellow. However, this effect is harmless and will typically subside within a few hours to a couple of days.

It’s always essential to stay hydrated and monitor any changes in urine color when taking any new supplement or medication.

Key Takeaways

  • Berberine can make your urine yellow due to the presence of natural pigments in the supplement.
  • Other factors like hydration levels, diet, medications and supplements, health conditions, and exercise can also influence urine color.
  • In addition to temporarily affecting urine color, berberine may cause other side effects such as digestive issues and drug interactions.
  • If you notice changes in urine color while taking berberine, it’s important to stay hydrated and monitor the duration of the change. Consult a healthcare provider if it persists or cannot be linked to any other factor.
  • Berberine has potential health benefits such as blood sugar management, cholesterol regulation, weight loss support, anti-inflammatory properties, and antimicrobial effects.

Also Read: Can Apple Cider Vinegar Make Your Urine Smell?


Is yellow urine from berberine harmful?

No, yellow urine from berberine is not harmful. The change in urine color is primarily due to the natural pigments present in the supplement and is a temporary effect.

It should resolve within a few hours to a couple of days. If you stay well-hydrated, eat a balanced diet, and monitor any other supplements or medications you are taking, you can be assured that this change in urine color is typically harmless.

How much berberine should I take?

The appropriate dosage of berberine can vary depending on individual health factors and specific health goals. Generally, a common dosage for adults is between 500 mg to 1500 mg per day, divided into two or three doses.

It is essential to follow the guidelines provided by a healthcare provider or the supplement manufacturer.

Can I take berberine with other medications?

Berberine may interact with certain medications, so it’s important to consult a healthcare provider before taking it alongside other medications.

Some antibiotics and anticoagulants are known to have potential interactions with berberine. It can also increase the effects of some drugs, like blood pressure medication, if taken together.

Can I take berberine while pregnant or breastfeeding?

There is limited research on the safety of berberine for pregnant or breastfeeding women. It’s important to consult a healthcare provider before taking any supplements while pregnant or breastfeeding.

Useful Resources

WebMD- Berberine 

Cleveland Clinic- Urine Changes

Healthline- What Causes Bright-Yellow Urine


The content of this article is provided for informational purposes only and should not be considered a replacement for professional medical advice, diagnosis, or treatment. It is important to seek professional medical advice and not disregard it or delay seeking it based on the information read here. While we strive to provide accurate and reliable information, we cannot guarantee its completeness, accuracy, reliability, suitability, or availability for any purpose. Using the information in this document is your responsibility and carries inherent risks. We are not liable for any losses or damages resulting from the use of our content.


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